Sustainable Nanochemistry

Polymer Theranostics & Bioenergy


3. Core-shell cationic polymers, International Patent Nº. 50030, 01.10.2021.
2. Polímeros de núcleo-camada catiónicos, Portuguese Patent Nº. 116802, 01.10.2020.
1. Polímeros sintéticos com atividade catalítica, método de produção e usos dos mesmos, Portuguese Patent Nº. 115989, 18.12.2019.


66. Exploring the chemical space of urease inhibitors to extract meaningful trends and drivers of activity, N. Aniceto*, V.D.B. Bonifácio, R.C. Guedes, N. Martinho, J. Chem. Inf. Model. 2022 (accepted).
65. Lipid droplets in cancer: From composition and role to imaging and therapeutics. P. Antunes, A. Cruz, J. Barbosa, V.D.B. Bonifácio*, S.N. Pinto*, Molecules, 2022, 27, 991.
64. One-pot three-step mechanically assisted synthesis and catalytic performance of tripodal metallic complexes, R. Tedjini, R. Viveiros, T. Casimiro, V.D.B. Bonifácio*, React. Chem. Eng. 2021, 6, 2140.
The activation of endothelial cells relies on a ferroptosis-like mechanism: Novel perspectives in management of angiogenesis and cancer therapy, F. Lopes-Coelho, F. Martins, A. Hipólito, C. Mendes, C.O. Sequeira, R.F. Pires, A. Almeida, V.D.B. Bonifácio, S.A. Pereira, J. Serpa*, Front. Oncol. 2021.
Intrinsic acetamide brush-off by polyurea biodendrimers, N. Martinho*, R.F. Pires, M. Zloh, V.D.B. Bonifácio*, J. Mater. Chem. B 2021, 9, 33713376.
Conventional vs microwave- or mechanically-assisted synthesis of dihomooxacalix[4]arene phthalimides: NMR, X-ray and photophysical analysis, A.S. Miranda, P.M. Marcos, J.R. Ascenso, M.P. Robalo*, V.D.B. Bonifácio, M.N. Berberan-Santos, N. Hickey, S. Geremia, Molecules 2021, 26(6), 1503.
Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled drug release, M. Lopes, R. Restani, M.P. Carvalho, I. Correia, A. Aguiar-Ricardo, V.D.B. Bonifácio*, React. Funct. Polym. 2021, 161, 104846.
Carbapenem-resistant Klebsiella pneumoniae clinical isolates: In vivo virulence assessment in Galleria mellonella and potential therapeutics by polycationic oligoethyleneimine, D. Mil-Homens, M. Martins, J. Barbosa, G. Serafim, M.J. Sarmento, R.F. Pires, V. Rodrigues, V.D.B. Bonifácio*, S.N. Pinto*, Antibiotics 2021, 10(1), 56.
58. Cysteine metabolic circuitries: Druggable targets in cancer, V.D.B. Bonifácio*, S.A. Pereira*, J. Serpa*, J.B. Vicente*, Br. J. Cancer 2021, 124, 862–879.
57. Osteogenic differentiation of human mesenchymal stem cells by the single action of luminescent polyurea oxide biodendrimers, R.F. Pires, J.Conde*, V.D.B. Bonifa╠ücio*, ACS Appl. Bio Mater. 2020, 3(12) 9101–9108.
. Ovarian cancer biomarkers: Moving forward in early detection, V.D.B. Bonifácio* in Tumor microenvironment - The main driver of metabolic adaptation, Springer Nature, Switzerland, 2020.
55. Nano-in-micro sildenafil dry powder formulations for the treatment of pulmonary arterial hypertension disorders: The synergic effect of POxylated polyurea dendrimers, PLGA and cholesterol, R.B. Restani, M.T. Tavares, R.F. Pires, P.V. Baptista, A.R. Fernandes, T. Casimiro, V.D.B. Bonifácio*, A. Aguiar-Ricardo*, Part. Part. Syst. Charact. 2020, 37 (6), 1900447.
54. Polyurea dendrimer folate-targeted nanodelivery of L-buthionine sulfoximine as a tool to tackle ovarian cancer chemoresistance, A. Cruz, P. Mota, C. Ramos, R.F. Pires, C. Mendes, J. Pais, S.C. Nunes, V.D.B. Bonifácio*, J. Serpa*, Antioxidants 2020, 9, 133. Part of the special issue "When the Anticancer Strategies Modulating Oxidative Stress Meet Nanomedicine: New Perspectives".
53. Photodiode-like behavior of jelly dye-sensitized donor-acceptor dendrimers, R.F. Pires, A. Charas, J. Morgado, T. Casimiro, V.D.B. Bonifácio*, J. Appl. Pol. Sci. 2020, 137, 48635.
52. Targeting glutathione and cystathionine β-synthase in ovarian cancer treatment by selenium-chrysin polyurea dendrimers nanoformulation, I. Santos, C. Ramos, C. Mendes, C.O. Sequeira, C.S. Tomé, D.G.H. Fernandes, P. Mota, R.F. Pires, D. Urso, A. Hipólito, A.M.M. Antunes, J.B. Vicente, S.A. Pereira, V.D.B. Bonifácio, S.C. Nunes, J. Serpa*, Nutrients 2019, 11, 2523.
51. L-Buthionine sulfoximine detection and quantification in polyurea dendrimer nanoformulations, P. Mota, R.F. Pires, J. Serpa, V.D.B. Bonifácio*, Molecules 2019, 24(17), 3111.
50. Green development of polymeric dummy artificial receptors with affinity for amide-based pharmaceutical impurities, R. Viveiros, V.D.B. Bonifácio, W. Heggie, T. Casimiro*,  ACS Sustain. Chem. Eng. 2019 ,7(18) 15445.
49. Photodiodes: Principles and recent advances, R.F. Pires*, V.D.B. Bonifácio*, J. Mater. NanoSci. 2019, 6(2), 38.
48. POxylated Dendrimer-based nano-in-micro dry powder formulations for inhalation chemotherapy, R.B. Restani, R.F. Pires, A. Tolmatcheva, R. Cabral, P.V. Baptista, A.R. Fernandes, T. Casimiro, V.D.B. Bonifácio*, Ana Aguiar-Ricardo*, ChemistryOpen 2018, 7(10), 772. Dedicated to Prof. Martyn Poliakoff in the occasion of his 70th birthday. Cover Feature of ChemistryOpen issue 10, 2018.
47. Synthesis of fluorescent water-soluble oligo(oxazoline-ethylenimine) block copolymers, R.F. Pires*, J. Frutuoso, A.S. Cortes, A. Aguiar-Ricardo, V.D.B. Bonifácio*, Adv. Mat. Lett. 2018, 9(5), 383.
46. Polyureas, R.F. Pires*, V.D.B. Bonifácio*, Kirk-Othmer Encyclopedia of Chemical Technology, 1, 2017.
45. Aerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung delivery, A.S. Silva, A.M. Sousa, R.P. Cabral, M.C. Silva, C.Costa, S.P. Miguel, V.D.B. Bonifácio, T. Casimiro, I.J. Correia, A. Aguiar-Ricardo, Int. J. Pharm. 2017, 519, 240.
44. 40 Years of chemistry divulgation in Portugal, V.D.B. Bonifácio*, Química SPQ 2017, 145, 67-71.
43. Molecular weight determination by luminescent chemoenzymatics, R.F. Pires,  A. Moro, A. Lourenço, J.C. Lima, T. Casimiro*, V.D.B. Bonifácio*, ChemistrySelect 2016, 1, 6818.
42. Nano-in-micro POxylated polyurea dendrimers and chitosan dry powder formulations for pulmonary delivery, R.B. Restani, A.S. Silva, R.F. Pires, R. Cabral, I.J. Correia, T. Casimiro, V.D.B. Bonifácio*, A. Aguiar-Ricardo*, Part. Part. Syst. Charact. 2016, 33, 851.
41. Nanogold POxylation: Towards always-on fluorescent lung cancer targeting, A.S. Silva, M.C. Silva, S.P. Miguel, V.D.B. Bonifácio*, I.J. Correia, A. Aguiar-Ricardo*, RSC Adv. 2016, 6, 33631. Dedicated to Prof. Ana Lobo in the occasion of her 70th birthday.
40. Hell's chemistry - Química kamikaze, V.D.B. Bonifácio*, Química SPQ, 2016, 142, 11.
39. Mechanochemistry in action: grind and go! - Mecanoquímica: Moer, esmagar... reacção! V.D.B. Bonifácio*, Química SPQ 2016, 141, 17. Article featured as cover of issue 141 (April-June 2016) of Química SPQ.
38. Supercritical carbon dioxide design strategies: from drug carriers to soft killers, A. Aguiar-Ricardo, V.D.B. Bonifácio, T. Casimiro, V.G. Correia, Phil. Trans. R. Soc. A 2015, 373, 20150009.
37. POxylated polyurea dendrimers: Smart core-shell vectors with IC50 lowering capacity, R.B. Restani, J. Conde, R.F. Pires, P. Martins, A.R. Fernandes, P.V. Baptista, V.D.B. Bonifácio*, A. Aguiar-Ricardo*, Macromol. Biosci. 2015, 15, 1045.
36. Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging, A.S. Silva, V.P. Raje, V.D.B. Bonifácio*, P.S. Branco, P.F.B. Machado, I.J. Correia, A. Aguiar-Ricardo*, RSC Adv. 2015, 5, 10733.
35. Polyurea dendrimer-perylene self-imprinted nanoshells for trace explosives detection, A. Bragança, M. Araújo, V.D.B. Bonifácio*, Part. Part. Syst. Charact. 2015, 32, 98.
34. Teaching chemistry with chess codes - A química em código(s), V.D.B. Bonifácio*, Química SPQ 2015, 136, 59.
33. Supercritical CO2-assisted synthesis of an ultrasensitive amphibious quantum dot-molecularly imprinted sensor, A. Lourenço, R. Viveiros, A. Moro, J.C. Lima, V.D.B. Bonifácio*, T. Casimiro*, RSC Adv. 2014, 4, 63338.
32. Polyurea dendrimer for efficient cytosolic siRNA delivery, R.B. Restani, J. Conde, P.V. Baptista, M.T. Cidade, A.M. Bragança, J. Morgado, I.J. Correia, A. Aguiar-Ricardo*, V.D.B. Bonifácio*, RSC Adv. 2014, 4, 54872.
31.  Natural melanin: A potential pH-responsive drug release device, M. Araújo, R. Viveiros, T.R. Correia, I.J. Correia, V.D.B. Bonifácio, T. Casimiro, A. Aguiar-Ricardo*, Int. J. Pharm. 2014, 469, 140.
30. Reborn water-soluble CdTe quantum dots, A. Lourenço, T. Casimiro*, V.D.B. Bonifácio*, Talanta 2014, 125, 319.
29. Solvent-free and catalyst-free chemistry: A benign pathway to sustainability, M.B. Gawande*, V.D.B. Bonifácio*, R. Luque, P.S. Branco, R.S. Varma*, ChemSusChem 2014, 7, 24. One of the 25 most accessed articles from ChemSusChem. The most-accessed chemistry article from ChemPubSoc Europe, ACES and GDCh journals.
28. Química, tablets e telemovéis inteligentes: Prémios Nobel da química 1901-2011 em código QR, V.D.B. Bonifácio*, Química SPQ 2014, 132, 59.
27. A green approach toward antibody purification, T.G. Barroso, V.D.B. Bonifácio, A.C.A. Roque*, A. Aguiar-Ricardo*, J. Mol. Recognit. 2013, 26, 662.
26. Offering QR-code access to information on Nobel prizes in chemistry, 1901–2011, V.D.B. Bonifácio*, J. Chem. Educ. 2013, 90, 1401. Article selected by the ACS Office of Public Affairs for a Press Pac, a package of announcements that ACS sends to more than 4000 journalists around the world.
25. Sonified infrared spectra and their interpretation by blind and visually impaired students, F. Pereira*, J.C. Ponte-e-Sousa, R.P.S. Fartaria, V.D.B. Bonifácio, P. Mata, J. Aires-de-Sousa, A.M. Lobo, J. Chem. Educ. 2013, 90, 1028. Article highlighted in C&EN magazine: The sound of spectra, Chem. Eng. News, 2013, 91, 30.
24. Magnetically recyclable magnetite-ceria (Nanocat-Fe-Ce) nanocatalysts - applications in multicomponent reactions under benign conditions, M.B. Gawande*, V.D.B. Bonifácio, R.S. Varma, P.S. Branco*, I.D. Nogueira, N. Bundaleski, C.A.A. Ghumman, O.M.N.D. Teodoro, Green Chem. 2013, 15, 1226.
23. Benign by design: Catalyst-free in-water, on-water, green chemical methodologies in organic synthesis, M.B. Gawande*, V.D.B. Bonifácio*, R. Luque, P.S. Branco, R.S. Varma*, Chem. Soc. Rev. 2013, 42, 5522. Article highlighted in the OBC Blog. Chemistry in water.
22. NavMol 2.0: A molecular structure navigator/editor for blind and visually impaired users, R.P.S. Fartaria*, F. Pereira, V.D.B. Bonifácio, P. Mata, J. Aires-de-Sousa*, A.M. Lobo, Eur. J. Org. Chem.  2013, 1415.
21. Anti-biofouling 3D porous systems: The blend effect of oxazoline-based oligomers on chitosan scaffolds, V.G. Correia, M. Coelho, T. Barroso, V.P. Raje, V.D.B. Bonifácio, T. Casimiro, M.G. Pinho, A. Aguiar-Ricardo*, Biofouling 2013, 29, 273.
20. Dual on-off and off-on switchable oligoaziridine biosensor, V.P. Raje, P.I. Morgado, M.P. Ribeiro, I.J. Correia, V.D.B. Bonifácio*, P.S. Branco, A. Aguiar-Ricardo*, Biosen. Bioelectron. 2013, 39, 64. Article highlighted in Advances in Engineering.
19. Green synthesis and anti-tubercular activity of fluorinated pyrazoline derivatives, S.N. Shelke*, G.R. Mhaske, V.D.B. Bonifácio, M.B. Gawande*, Bioorg. Med. Chem. Lett. 2012, 22, 5727.
18. Blue emission of carbamic acid oligooxazoline biotags, V.D.B. Bonifácio*, V.G. Correia, M.G. Pinho, J.C. Lima, A. Aguiar-Ricardo*, Mater. Lett. 2012, 81, 205.
17. Supercritical fluid technology as a new strategy for the development of semi-covalent molecularly imprinted materials, M. da Silva, R. Viveiros, V.D.B. Bonifácio, A. Aguiar-Ricardo, T. Casimiro*, RSC Adv. 2012, 2, 5075.
16. Biocompatible polyurea dendrimers with pH-dependent fluorescence, R.B. Restani, P.I. Morgado, M.P. Ribeiro, I.J. Correia, A. Aguiar-Ricardo, V.D.B. Bonifácio*, Angew. Chem. Int. Ed. 2012, 51, 5162; Angew. Chem. 2012, 124, 5252.
15. QR coded audio periodic table: A mobile-learning tool, V.D.B. Bonifácio*, J. Chem. Educ. 2012, 89, 552.  Article highlighted in the JCE cover description. The most read JCE article in 2012 (Q1/Q2).
14. Ensinar química com telemovéis inteligentes: A tabela periódica em código QR, V.D.B. Bonifácio*, Química SPQ 2012, 127, 71.
13. O-Substituted N-oxy arylsulphinamides and sulphonamides in Michael reactions, V.D.B. Bonifácio*, R.P. Kumar, S. Prabhakar, A.M. Lobo, Arkivoc 2011, X, 266.
12. Oxazoline-based antimicrobial oligomers: synthesis by CROP using supercritical CO2, V.G. Correia, V.D.B. Bonifácio, V.P. Raje, T. Casimiro, G. Moutinho, C.L. da Silva, M.G. Pinho, A. Aguiar-Ricardo*, Macromol. Biosci. 2011, 11, 1128.  Article featured as back cover of issue 8 (August 11, 2011) of Macromolecular Bioscience.
11. MOLinsight: A web portal for the processing of molecular structures by blind students, F. Pereira*, J. Aires de Sousa, V.D.B. Bonifácio, P. Mata, A.M. Lobo, J. Chem. Educ. 2011, 88, 361.
10. Development of functional mesoporous microparticles for controlled drug delivery, R.B. Restani, V.G. Correia, V.D.B. Bonifácio*, A. Aguiar-Ricardo*, J. Supercrit. Fluid. 2010, 55, 333.
9. Ultrasensitive microchip sensor based on boron-containing polyfluorene nanofilms, C. Ribeiro*, P. Brogueira, G. Lavareda, C.N. Carvalho, A. Amaral, L. Santos, J. Morgado, U. Scherf, V.D.B. Bonifácio*, Biosen. Bioelectron. 2010, 26, 1662.
8. Synthesis of thiosulfonate bridged bromofluorene end-capping reagents, V.D.B. Bonifácio*, J. Morgado, U. Scherf, Synlett 2010, 9, 1333. Article highlighted in Thieme Synfacts: Sticky caps for polymers, T.M. Swager, Synfacts 2010, 8, 895.
7. Dehydroindigo, the forgotten indigo and its contribution to the color Maya blue, R. Rondao, S. Seixas de Melo*, V.D.B. Bonifácio, M.J. Melo, J. Phys. Chem. A 2010, 114, 1699.
6. Chiral aziridination of olefins using a chiral sulfinamide as the nitrogen source, V.D.B. Bonifácio, C. Gonzalez-Bello, H.S. Rzepa, S. Prabhakar*, A.M. Lobo*, Synlett 2010, 1, 145.
5. Polyfluorenes with on-chain dibenzoborole units - synthesis and anion-induced photoluminescence quenching, V.D.B. Bonifacio*, J. Morgado, U. Scherf, J. Polym. Sci. Part A: Polym. Chem. 2008, 46, 2878.
4. Palladium(II) mediated aziridination of olefins with bromamine-T as the nitrogen source: scope and mechanism, A.M.M. Antunes, V.D.B. Bonifácio, S. Nascimento, P.S. Branco*, A.M. Lobo, S. Prabhakar, Tetrahedron 2007, 63, 7009.
3. Meldrum's acid, V.D.B. Bonifácio*, Synlett 2004, 9, 1649.
2. Photochemistry of flavothione and hydroxyflavothiones: mechanisms and kinetics, A.L. Maçanita*, F. Elisei, G.G. Aloisi, F. Ortica, V.D.B. Bonifácio, A. Dias, E. Leitao, M.J. Caldeira, C.D. Maycock, R.S. Becker, Photochem. Photobiol. 2003, 77, 22.
1. Photophysical properties of hydroxy-substituted flavothiones, F. Elisei*, J.C. Lima, F. Ortica, G.G. Aloisi, M. Costa, E. Leitao, I. Abreu, A. Dias, V.D.B. Bonifácio, J. Medeiros, A.L. Maçanita, R.S. Becker*, J. Phys. Chem. A 2000, 104, 6095.


Reddit para a Química?, V.D.B. Bonifácio, Química SPQ, 2021, 163, 303.
• Em sintonia no
DiscordMe, V.D.B. Bonifácio, Química SPQ, 2021, 163, 303.
Química com tiktok?, V.D.B. Bonifácio, Química SPQ, 2021, 162, 75.
Química em tempo real, V.D.B. Bonifácio, Química SPQ, 2021, 162, 75.
Quimiofilatelia, V.D.B. Bonifácio, Química SPQ, 2021, 161, 71.
Química em blocos, V.D.B. Bonifácio, Química SPQ, 2021, 161, 71.
A química de quase tudo, V.D.B. Bonifácio, Química SPQ, 2021, 160, 63.
Jogar com Mecanismos?, V.D.B. Bonifácio, Química SPQ, 2021, 160, 63.
Aprender química online, V.D.B. Bonifácio, Química SPQ, 2020, 159, 65.
Histórias de desencantar, V.D.B. Bonifácio, Química SPQ, 2020, 159, 65.
Um olhar químico: Viagens pelo laboratório, V.D.B. Bonifácio, Química SPQ, 2020, 158, 63.
Bioquímica para miúdos: Aprender de forma divertida, V.D.B. Bonifácio, Química SPQ, 2020, 158, 63.
Produção de monóxido de carbono por descarboxilação de ferivados de 3-hidroxiflavonas usando LEDs, V.D.B. Bonifácio, Química SPQ, 2020, 156, 18.
Fluoração seletiva por catálise fotorredutora usando sais arilssulfónio e LEDs, V.D.B. Bonifácio, Química SPQ, 2020, 156, 19.


Proline derivatives in organic synthesis, V.D.B. Bonifácio. Org. Chem. Highlights, 2007, March 25.
Enantioselective high-throughput synthesis, V.D.B. Bonifácio. Org. Chem. Highlights, 2006, October 5.
Chiral N-heterocyclic carbenes, V.D.B. Bonifácio. Org. Chem. Highlights, 2006, July 25.
Asymmetric hetero-Diels-Alder reactions, V.D.B. Bonifácio. Org. Chem. Highlights, 2006, April 05.
Enantioselective aza-Baylis Hillman reaction, V.D.B. Bonifácio. Org. Chem. Highlights, 2006, January 30.
Enantioselective aza-Henry and aza-Michael Reactions, V.D.B. Bonifácio. Org. Chem. Highlights, 2005, October 25.
Enantioselective sulfoxidation, V.D.B. Bonifacio. Org. Chem. Highlights, 2005, September 25.
Organic synthesis in water, V.D.B. Bonifácio. Org. Chem. Highlights, 2005, July 25.
Hypervalent iodine chemistry, V.D.B. Bonifácio. Org. Chem. Highlights, 2005, May 25.
Borane complexes in organic chemistry, V.D.B. Bonifácio. Org. Chem. Highlights, 2005, March 24.
Boranes in Cancer Therapy, V.DB. Bonifácio. Org. Chem. Highlights, 2005, February 25.
The chiral sulfur connection, V.D.B. Bonifácio.  Org. Chem. Highlights, 2004, December 24.
Design and synthesis of antimalarial endoperoxides, V.D.B. Bonifácio. Org. Chem. Highlights, 2004, October 25.